https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50249 Wed 28 Feb 2024 16:16:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26369 Wed 22 Mar 2023 16:20:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24130 Wed 15 Dec 2021 16:08:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12932 Wed 11 Apr 2018 16:18:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15374 Wed 11 Apr 2018 15:48:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16063 Wed 11 Apr 2018 10:47:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16475 Wed 11 Apr 2018 10:41:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32096 Wed 09 Feb 2022 15:57:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50343 Wed 06 Mar 2024 14:16:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55150 Tue 16 Apr 2024 15:25:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46008 Tue 08 Nov 2022 17:21:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41373 Tue 02 Aug 2022 15:27:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32076 Thu 27 Jan 2022 15:57:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40385 p < 0.001); about 25% of the variation in pregnancy loss was attributable to differences between clusters. Conclusion: IPV against women, including partner controlling behaviour, is significantly associated with pregnancy loss in Ethiopia. Therefore, there is a clear need to develop IPV prevention strategies and to incorporate IPV interventions into maternal health programs.]]> Thu 11 Aug 2022 15:01:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30931 41 completed weeks of gestation (late-term) would show changes consistent with aging that would also be present in placentas associated with stillbirths. Objective: We sought to determine whether placentas from late-term pregnancies and unexplained stillbirth show oxidative damage and other biochemical signs of aging. We also aimed to develop an in vitro term placental explant culture model to test the aging pathways. Study Design: We collected placentas from women at 37-39 weeks’ gestation (early-term and term), late-term, and with unexplained stillbirth. We used immunohistochemistry to compare the 3 groups for: DNA/RNA oxidation (8-hydroxy-deoxyguanosine), lysosomal distribution (lysosome-associated membrane protein 2), lipid oxidation (4-hydroxynonenal), and autophagosome size (microtubule-associated proteins 1A/1B light chain 3B, LC3B). The expression of aldehyde oxidase 1 was measured by real-time polymerase chain reaction. Using a placental explant culture model, we tested the hypothesis that aldehyde oxidase 1 mediates oxidative damage to lipids in the placenta. Results: Placentas from late-term pregnancies show increased aldehyde oxidase 1 expression, oxidation of DNA/RNA and lipid, perinuclear location of lysosomes, and larger autophagosomes compared to placentas from women delivered at 37-39 weeks. Stillbirth-associated placentas showed similar changes in oxidation of DNA/RNA and lipid, lysosomal location, and autophagosome size to placentas from late-term. Placental explants from term deliveries cultured in serum-free medium also showed evidence of oxidation of lipid, perinuclear lysosomes, and larger autophagosomes, changes that were blocked by the G-protein-coupled estrogen receptor 1 agonist G1, while the oxidation of lipid was blocked by the aldehyde oxidase 1 inhibitor raloxifene. Conclusion: Our data are consistent with a role for aldehyde oxidase 1 and G-protein-coupled estrogen receptor 1 in mediating aging of the placenta that may contribute to stillbirth. The placenta is a tractable model of aging in human tissue.]]> Thu 09 Dec 2021 11:03:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7424 Thu 06 Oct 2022 14:46:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36079 5 times daily during their first pregnancy at greater risk of having a stillbirth (aOR 5.89; 95% CI 1.70, 20.3) than less frequent users (aOR 1.67; 95% CI 0.65, 4.29). Estimates were robust to extreme assumptions about missing exposure data. Discussion and Conclusions: STC during pregnancy was associated with an increased risk of stillbirth. This finding adds to the urgency of need for smokeless tobacco control strategies to be implemented in South Asia.]]> Thu 06 Feb 2020 11:09:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13880 Sat 24 Mar 2018 08:25:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5358 Sat 24 Mar 2018 07:43:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33234 Mon 23 Sep 2019 11:54:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32324 Mon 23 Sep 2019 11:14:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44174 Mon 10 Oct 2022 10:13:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39080 Fri 06 May 2022 12:40:34 AEST ]]>